(KO Validated) ADRBK1 Polyclonal Antibody

(KO Validated) ADRBK1 Polyclonal Antibody

ABCE07123
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Dilution

WB 1:500-1:2000 IHC 1:50-1:200

Product Details

Isotype IgG
Concentration 1mg/mL
Storage Store at -20°C. Avoid freeze / thaw cycles.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Affinity purification
Research Areas Cancer, Neuroscience, Signal Transduction
Conjugation Unconjugated

Immunogen Details

Immunogen Recombinant fusion protein of human ADRBK1 (NP_001610.2).
Abbre ADRBK1
Synonyms GRK2,ADRBK1,BARK1,BETA-ARK1
Swissprot P25098
Gene ID 156
Calculated MW 79kDa
Observed MW 80kDa
Cellular Localization Cytosol,Plasma Membrane,Other locations:cilium,cytoplasm,membrane
Tissue Specificity Expressed in peripheral blood leukocytes.

Background

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

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